FIGURE 1.

Expression levels of miR-223-3p and -5p were dynamically regulated in mouse ischemic/reperfused hearts. A and B, alteration of miR-223-3p and -5p levels in heart subjected in vivo to 30-min ischemia followed by reperfusion. C and D, both strands of pre-miR-223 were up-regulated in ex vivo hearts subjected to 45-min ischemia followed by 2-h reperfusion (error bars represent mean ± S.D.; n = 6 for in vivo sham and ischemic groups; n = 4 for in vivo 1-h, 4-h and n = 5 for 24-h reperfusion groups; n = 4 for ex vivo 45-min ischemia and 2-h reperfusion groups; *, p < 0.01 versus sham controls).