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Treatment of pre-miR-223 KO mice with Nec-1s largely rescued I/R-induced myocardial damage ex vivo and in vivo. A–D, cardiac function recovery was significantly improved in not only WT mice but also pre-miR-223 KO mice upon ex vivo 30-min ischemia followed by 1-h reperfusion (n = 5 for KO and n = 6 for WT in buffer controls; n = 6 for KO and WT in Nec-1s-treated group; *, p < 0.005). Error bars represent mean ± S.D.
