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. 2016 Sep 16;6:33398. doi: 10.1038/srep33398

Figure 2. The pan-cancer network.

Figure 2

(A) Topological organization of the pan-cancer network which show six modular subnetworks marked with different colours. (B) Enriched biological functions of pan-cancer subnetworks. Each row represents a GO BP term and each column corresponds to a pan-cancer subnetwork. For each subnetwork, FDRs are calculated using Fisher’s exact test and Benjamini-Hochberg correction59. For each subnetwork, we only show the top five significant terms. Each pixel represents a −log(FDR) (FDR ≤ 0.01). FDRs under 1 × 10−10 are changed into 1 × 10−10 for convenience. (C) Pan-cancer subnetworks relate to prognostic information. For a given cancer type and a given pan-cancer subnetwork/module, patients are divided into two groups based on the median of the ME score. The Kaplan-Meier survival curves are drawn for each group. Four representative cases are shown65 with P values calculated by log rank sum test. Each subfigure corresponds to a subnetwork and a cancer type.