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. 2016 Sep 16;6:33444. doi: 10.1038/srep33444

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Copyright © 2016, The Author(s)

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Proteasome inhibition effects of Cu(II) ions monitored by luminescent probes (ProteasomeGlo^©) in HeLa Cells. Cells were treated with different amounts of Cu(II) (blue bars) and also in the presence of (100 μM) NAC (red bars) for 24 h. The effect of epoxomycin (2 nM) on proteasome activity is also reported as a control (green bar). Data from three independent experiments were normalized to untreated controls and are reported as means ± standard deviation. By one-way ANOVA and Turkey’s multiple comparison test, ChT-L activity in the presence of Cu(II) 20 μM are found to be significantly lower (*p < 0.05) than those at 10 μM Cu(II). Anlogously, ChT-L activity in the presence of Cu(II) 80 μM are found to be significantly lower (*p < 0.05) than those at 40 μM Cu(II) if NAC is present in the medium.