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. 2016 Sep 16;6:33453. doi: 10.1038/srep33453

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Copyright © 2016, The Author(s)

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(A) TransAM^® assay showing decreased p65 activation indicative of NF-κB pathway activity following OCA treatment in the therapeutic study arm. (B) IκBα is increased significantly after OCA administration in the prophylactic study arm. NF-κB, nuclear transcription factor-kappa beta; TAA, thioacetamide; OCA, obeticholic acid; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.