Table 1. Physical and biochemical findings in blood plasma amongst different experimental groups.
TAA (n = 8) | TAA + OCA (n = 9) | P-value | TAA + 4 (n = 6) | TAA + 4 + OCA (n = 9) | P-value | |
---|---|---|---|---|---|---|
Body weight (g) | 319 ± 11 | 302 ± 11 | 0.27 | 395 ± 9 | 410 ± 12 | 0.38 |
Overall average dose TAA (g/L) | 520 ± 13 | 478 ± 23 | 0.15 | 478 ± 19 | 450 ± 21 | 0.31 |
Liver weight | 22 ± 2 | 22 ± 2 | 0.89 | 24 ± 2 | 22 ± 2 | 0.32 |
Albumin (g/L) | 33.5 ± 0.8 | 35.1 ± 1.2 | 0.28 | 35.2 ± 1.0 | 36.6 ± 0.7 | 0.45 |
AST (IU/L) | 85 ± 4 | 87 ± 7 | 0.76 | 100 ± 4 | 93 ± 4 | 0.68 |
ALT (IU/L) | 75 ± 4 | 66 ± 3 | 0.34 | 97 ± 4 | 79 ± 4 | *0.01 |
Bilirubin (mg/dL) | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.92 | 0.0 ± 0.0 | 0.0 ± 0.1 | 0.90 |
TAA, thioacetamide; OCA, obeticholic acid; AST, aspartate aminotransferase; ALT, alanine aminotransferase.