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. 2016 Sep 2;7:12685. doi: 10.1038/ncomms12685

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Copyright © 2016, The Author(s)

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(a) Representative images of high-grade PanIN and PDAC from 6-week-old Pdx1-Cre-K-MADM-p53 mice show uniform green (GFP+/tdTomato−, p53^KO/KO) labelling in these advanced lesions. Blue, DAPI-stained nuclei. Scale bars, 100 μm. (b) Absolute quantification of high-grade PanINs/PDAC in 6-week-old Pdx1-Cre-K-MADM-p53 mice (n=5 mice total). Expected numbers are based on 1:1 stoichiometric ratio of green and red cell generation, and were not observed (P<0.001, χ²-test). (c) CLARITY image of pancreas from a 13-week-old Pdx1-Cre-K-MADM-p53 mouse showing grossly diseased pancreas (PanINs interspersed with normal pancreatic tissue) without overt PDAC. Right image shows zoomed in area from left image. Scale bars, 1 mm (left image) and 100 μm (right image). (d) CLARITY image of PDAC from a 13-week-old Pdx1-Cre-K-MADM-p53 mouse. Right image shows zoomed in area from left image. Scale bars, 1 mm (left image) and 100 μm (right image).