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. 2016 Sep 2;7:12685. doi: 10.1038/ncomms12685

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Copyright © 2016, The Author(s)

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(a) IHC for p53 in LSL-Kras^G12D/Kras^WT; p53^{LSL-R172H/flox} low-grade adenomas and mixed-grade adenocarcinomas revealed p53 staining only in high-grade lung tumour cells. (b) IHC for p53 in Pdx1-Cre; LSL-Kras^G12D/Kras^WT; p53^LSL-R172H/WT adult pancreas revealed increased p53 expression in higher-grade pancreatic lesions. Arrows show low-grade PanINs. (c) A subset of acinar-to-ductal metaplasia (ADM) cells expressed p53 (arrows). (d) A subset of low-grade PanIN cells expressed p53 (arrowheads). Scale bars, 100 μm (all).