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. 2016 Sep 2;7:12685. doi: 10.1038/ncomms12685

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Copyright © 2016, The Author(s)

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(a) IHC for p19ARF in Pdx1-Cre; LSL-Kras^G12D/Kras^WT; p53^LSL-R172H/WT tumours showed expression throughout pancreatic tumorigenesis from early acinar-to-ductal metaplasia (ADM) and PanIN lesions to PDAC. (b) IHC for p19ARF exhibited expression in LSL-Kras^G12D/Kras^WT; p53^flox/flox lung adenocarcinomas but not adenomas. (c) IHC for p19ARF in Pdx1-Cre; LSL-Kras^G12D/Kras^WT (KC) tumours, lacking p53 mutation, displayed expression throughout pancreatic tumorigenesis. These data suggest that p53 mutation in a does not induce p19ARF by feedback upregulation, as has been previously described²⁸. Scale bars, 100 μm (all).