Table 4.

Haplotype, cannabis exposure, and their interaction effects on the anterior cingulum (right and left), operculum (right) and lingual gyrus (total volume).

	CANNABIS	CNR1	CNR1 × CANNABIS
HAPLOTYPE 12:
CGTA OR TGTA (ANY TA)^a	*	0.004	0.002^b	RT ANT CINGULUM
TATA^a	*	0.028	0.004^b	RT ANT CINGULUM
HAPLOTYPE 34
CTTG OR TTTG (ANY TG)^a	0.010	0.045	0.033	OPERCULUM RT
TTTT^a	0.040	*	*	LINGUAL GYRUS
CTTG OR TTTG (ANY TG)^a	0.050	*	*	LINGUAL GYRUS
HAPLOTYPE 12= rs806368 and rs1049353^c
HAPLOTYPE 34= rs2023239 and rs6454674^d

Analyses were corrected for family ID, sex, SES, Lifetime Use of Alcohol, Lifetime Use of Cigarettes, Prenatal Exposure to Alcohol, Prenatal Exposure to Cigarettes. Non-significant covariates were removed and analysis rerun for the final model presented here.

The final model included total amount of prenatal alcohol exposure as it was significant in the full model that included all covariates.

Using a Bonferroni correction and the conventional level of significance of 0.05, each of the four regions would need to have a p-value of <0.004. The interaction of cannabis use and CNR1 variation for the Right Anterior Cingulum are less than the required corrected value.

The frequency of haplotype 12 was 0.52, 0.26, and 0.22 for the 11, 12, and 21 haplotypes, respectively.

The frequency of haplotype 34 was 0.50, 0.27 and 0.24 for the 11, 12, and 21 haplotypes, respectively.