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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2016 May 5;233(13):2593–2605. doi: 10.1007/s00213-016-4306-x

Fig. 1.

Fig. 1

Premature responses, total trials, and reaction time were differentially affected by sex, reinforcer volume, and methylphenidate (MPH) dose. Asterisks (*) denote significant differences between sexes (p < 0.05). Daggers (†) represent differences within-subjects (p < 0.05). (A) Males and females showed similar increases in premature responding for a 30 μL water reinforcer. (B) Females, but not males showed increased premature responding in response to methylphenidate. (C) Females had a tendency to initiate more trials than males, although there were no differences at higher reinforcer volumes and (D) was not altered by methylphenidate. (E) There were no sex differences in reaction time across reinforcer volumes or (F) methylphenidate doses. Although there was a main effect of methylphenidate, the interaction with sex, in which females were more sensitive to methylphenidate, did not reach statistical significance (p = 0.056). Data are presented as means ± SEM, and are collapsed across MPH dose (panels A, C, E) or Reinforcer Volume (B, D, F) measure.