Table 2. Relationship between THBS2 protein expression and clinicopathologic characteristic of CRC patients.
| Characteristic | Number* | Cases of death (%) | Pa value | HR (95% CI) | Expression of THBS2 |
Pb value | ||
|---|---|---|---|---|---|---|---|---|
| G0-1 | G2 | G3 | ||||||
| Age (yr) | 0.256 | 1.513(0.741–3.091) | 0.014 | |||||
| ≤60 | 40 | 11(27.5%) | 19 | 18 | 3 | |||
| >60 | 60 | 24(40.0%) | 22 | 16 | 22 | |||
| Gender | 0.317 | 1.403(0.723–2.722) | 0.976 | |||||
| Male | 57 | 18(31.6%) | 23 | 20 | 14 | |||
| Female | 43 | 17(39.5%) | 18 | 14 | 11 | |||
| Site | 0.249 | 0.646(0.307–1.358) | 0.497 | |||||
| Colon | 59 | 23(40.0%) | 25 | 16 | 18 | |||
| Rectum | 39 | 10(25.6%) | 15 | 18 | 6 | |||
| Size (cm) | 0.997 | 1.001(0.498–2.013) | 0.806 | |||||
| ≤5 | 53 | 18(34.0%) | 23 | 16 | 14 | |||
| >5 | 39 | 14(35.9%) | 14 | 16 | 9 | |||
| Histological type | 0.417 | 1.393(0.6250–3.102) | 0.907 | |||||
| Tubular adenocarcinoma | 77 | 24(31.2%) | 33 | 25 | 19 | |||
| Others | 19 | 8(42.1%) | 7 | 8 | 4 | |||
| General type | 0.979 | 0.990(0.489–2.006) | 0.424 | |||||
| Ulcerated | 56 | 19(33.9%) | 23 | 16 | 17 | |||
| Others | 37 | 13(35.1) | 15 | 16 | 6 | |||
| Differentiation | 0.001 | 3.158(1.610–6.195) | 0.389 | |||||
| Well/moderate | 75 | 20(26.7%) | 31 | 28 | 16 | |||
| Poor/undifferentiated | 25 | 15(60%) | 10 | 6 | 9 | |||
| Lymph node metastasis | 0.001 | 3.402(1.646–7.030) | 0.008 | |||||
| Negative | 53 | 11(20.8%) | 27 | 17 | 9 | |||
| Positive | 42 | 22(52.4%) | 11 | 16 | 15 | |||
| Distant metastasis | 0.002 | 3.520(1.559–7.947) | 0.046 | |||||
| Negative | 80 | 22(27.5%) | 36 | 27 | 17 | |||
| Positive | 11 | 8(72.7%) | 2 | 4 | 5 | |||
| TNM stage | <0.001 | 4.649(2.084–10.374) | 0.001 | |||||
| I/II | 52 | 8(15.4%) | 28 | 17 | 7 | |||
| III/IV | 45 | 24(53.3%) | 12 | 16 | 17 | |||
| Expression of THBS2 | <0.001 | 3.782(2.313–6.184) | Multivariate COX | |||||
| G0-1 | 41 | 5(12.2%) | Pc value | HR (95% CI) | ||||
| G2 | 34 | 9(26.5) | <0.001 | 3.164(1.698–5.927) | ||||
| G3 | 25 | 21(84%) | ||||||
(1) Pa values for the cox proportional hazards regression model analysis the correlation between clinicopathologic characteristic with overall survival. (2) Pb value for the chi-squared test analysis the correlation between clinicopathologic characteristic. (3) Pc value for the multivariate COX proportional hazard model analysis the diagnose value of THBS2 after adjustment age, sex, differentiation, lymph node metastasis, distant metastasis and TNM stage.
*Some data were missed.