. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: JAMA Neurol. 2016 Sep 1;73(9):1125–1132. doi: 10.1001/jamaneurol.2016.1236

Table 2.

Neuropathological findings in PSEN1 A79V carriers

Case	Age at death (decade)	Brain weight (g)	ABC score for AD neuropathologic change (NIA-AA)³⁹				Other
Case	Age at death (decade)	Brain weight (g)	A (Aβ plaques)	B (neurofibrillary tangles)	C (neuritic plaques)	Level of AD neuropathologic change	Other
A	9^th	875	3	3	3	High	-
B	8^th	1,050	3	2	2	Intermediate	CVD: lacunar infarcts in thalamus and basal ganglia
D	9^th	940	3	3	3	High	-
E^*	8^th	960	3	3	3	High	CVD: lacunar infarcts in inferior parietal gyrus LBD: brainstem-predominant
F	9^th	1,250	3	3	3	High	-

NIA-AA, National Institute on Aging-Alzheimer’s Association criteria for the neuropathologic assessment of AD

Information extracted from autopsy report issued by outside center; CVD, cerebrovascular disease; LBD, Lewy body disease.