Figure 7.

CCL2 released from peripheral tissue plays an important role in contribution of the neointima formation. (A) Using chimeric mice model, the CCL2 in peripheral blood of indicated mice was subjected to a CCL2 Quantikine ELISA kit. The vessels sections of indicated mice at various time points were stained with hematoxylin–eosin, and the neointima area (the area between arrows) was shown in the represented images (B) scale bars, 50µm., and quantified in the graphs (C) shown as mean ± SEM of n = 5 mice/group. *p < .05, **p < .01, ***p < .001. Abbreviations: WT + CCL2^−/− BMT, wild type mice of which bone marrow was transplanted from CCL2^−/−mice; CCL2^−/−+WT BMT, CCL2^−/− mice of which bone marrow was transplanted from wild type mice.