Table 4.
Changes in cerebral glucose metabolism after 6 and 12 months of DBS-f in pre-selected regions of interest by age and by treatment group
| Age < 65 years | Age≥65 years | ||||||||||
| OFF | ON | OFF | ON | ||||||||
| Region | Visit | n | Mean ± SD | n | Mean ± SD | p-value | n | Mean ± SD | n | Mean ± SD | p-value |
| (SE Change) | (SE Change) | (SE Change) | (SE Change) | ||||||||
| Pre-Central Gyrus | Baseline | 6 | 6.57 ± 1.55 | 6 | 6.61 ± 0.76 | 0.95 | 15 | 6.11 ± 2.50 | 15 | 5.36 ± 2.17 | 0.39 |
| % Change 6 | 6 | –2.20 ± 6.26 | 6 | –0.97 ± 9.18 | 0.91 | 14 | –13.70 ± 7.62 | 13 | 19.87 ± 12.20 | 0.55 | |
| % Change 12 | 6 | –1.21 ± 12.47 | 6 | –4.70 ± 6.86 | 0.81 | 15 | –2.74 ± 8.34 | 14 | 19.10 ± 13.69 | 0.18 | |
| Post-Central Gyrus | Baseline | 6 | 6.48 ± 1.08 | 6 | 6.82 ± 0.67 | 0.52 | 15 | 6.00 ± 2.44 | 15 | 5.31 ± 2.14 | 0.42 |
| % Change 6 | 6 | –0.84 ± 6.90 | 6 | 1.55 ± 8.92 | 0.84 | 14 | –13.05 ± 7.58 | 13 | 20.91 ± 12.07 | 0.02 | |
| % Change 12 | 6 | 0.07 ± 12.56 | 6 | –2.53 ± 6.81 | 0.86 | 15 | –1.69 ± 8.41 | 14 | 20.29 ± 13.58 | 0.67 | |
| Temporal Association Cortex | Baseline | 6 | 5.79 ± 1.30 | 6 | 5.69 ± 0.69 | 0.88 | 15 | 5.44 ± 2.19 | 15 | 4.67 ± 1.87 | 0.31 |
| % Change 6 | 6 | –3.00 ± 6.92 | 6 | –4.30 ± 8.76 | 0.91 | 14 | –15.87 ± 6.96 | 13 | 17.78 ± 12.27 | 0.02 | |
| % Change 12 | 6 | –2.95 ± 12.58 | 6 | –8.68 ± 7.00 | 0.70 | 15 | –5.77 ± 7.65 | 14 | 14.07 ± 13.01 | 0.19 | |
| Hippocampus | Baseline | 6 | 4.66 ± 0.74 | 6 | 4.85 ± 0.45 | 0.61 | 15 | 3.94 ± 1.49 | 15 | 3.67 ± 1.50 | 0.63 |
| % Change 6 | 6 | –2.22 ± 7.56 | 6 | –2.61 ± 8.18 | 0.97 | 14 | –15.46 ± 6.88 | 13 | 18.74 ± 12.46 | 0.02 | |
| % Change 12 | 6 | –0.28 ± 13.26 | 6 | –5.58 ± 6.25 | 0.72 | 15 | –4.88 ± 7.71 | 14 | 16.57 ± 12.57 | 0.15 | |
| Parietal Association Cortex | Baseline | 6 | 5.96 ± 1.57 | 6 | 6.12 ± 0.64 | 0.83 | 15 | 5.84 ± 2.42 | 15 | 5.07 ± 2.06 | 0.36 |
| % Change 6 | 6 | –2.18 ± 6.86 | 6 | –1.17 ± 9.14 | 0.93 | 14 | –13.70 ± 7.62 | 13 | 19.87 ± 12.20 | 0.02 | |
| % Change 12 | 6 | –1.96 ± 11.93 | 6 | –5.93 ± 7.20 | 0.78 | 15 | –3.95 ± 8.18 | 14 | 17.45 ± 13.24 | 0.17 | |
| Occipital (Cuneus) | Baseline | 6 | 6.94 ± 1.76 | 6 | 7.11 ± 1.23 | 0.85 | 15 | 6.92 ± 2.84 | 15 | 5.63 ± 2.39 | 0.19 |
| % Change 6 | 6 | –1.39 ± 7.47 | 6 | –1.46 ± 9.28 | 1.00 | 14 | –14.54 ± 7.46 | 13 | 20.18 ± 12.76 | 0.02 | |
| % Change 12 | 6 | –0.08 ± 11.95 | 6 | –8.37 ± 7.05 | 0.56 | 15 | –4.43 ± 8.73 | 14 | 17.31 ± 13.59 | 0.18 | |
| Cerebellar Hemispheres | Baseline | 6 | 5.90 ± 0.52 | 6 | 6.29 ± 0.80 | 0.34 | 15 | 5.69 ± 2.22 | 15 | 5.09 ± 2.12 | 0.46 |
| % Change 6 | 6 | –1.34 ± 6.95 | 6 | –0.54 ± 9.20 | 0.95 | 14 | –13.86 ± 7.20 | 13 | 19.36 ± 12.95 | 0.03 | |
| % Change 12 | 6 | 1.72 ± 13.15 | 6 | –2.75 ± 6.82 | 0.77 | 15 | –2.34 ± 7.84 | 14 | 19.31 ± 13.40 | 0.17 | |