Table 3.
Genotype frequency of determined CYP2D6 genotypes and corresponding phenotypes.
| Predicted | Genotype | Frequency in Macedonians (%) | Frequency in Albanians (%) | Frequency in Romanies (%) |
|---|---|---|---|---|
| Ultrarapid metabolizer | *1xN/*1 | 0.01 | 0.00 | 0.00 |
| *1xN/*2 | 0.03 | 0.00 | 0.01 | |
| *2xN/*2 | 0.01 | 0.01 | 0.00 | |
| Extensive metabolizer | *1/*1 | 0.14 | 0.15 | 0.13 |
| *1/*2 | 0.20 | 0.13 | 0.17 | |
| *1/*9 | 0.00 | 0.00 | 0.01 | |
| *1/*10 | 0.02 | 0.00 | 0.00 | |
| *1/*29 | 0.01 | 0.00 | 0.00 | |
| *2/*29 | 0.01 | 0.00 | 0.00 | |
| *1/*41 | 0.05 | 0.08 | 0.12 | |
| *2/*2 | 0.06 | 0.05 | 0.07 | |
| *2/*3 | 0.01 | 0.02 | 0.00 | |
| *2/*41 | 0.05 | 0.03 | 0.17 | |
| Intermediate metabolizer | *1/*3 | 0.01 | 0.03 | 0.01 |
| *1/*4 | 0.13 | 0.17 | 0.07 | |
| *1/*5 | 0.02 | 0.02 | 0.01 | |
| *1/*6 | 0.00 | 0.02 | 0.01 | |
| *2/*4 | 0.09 | 0.12 | 0.02 | |
| *2/*5 | 0.01 | 0.00 | 0.00 | |
| *2/*6 | 0.00 | 0.01 | 0.00 | |
| *41/*41 | 0.03 | 0.02 | 0.03 | |
| *9/*41 | 0.00 | 0.01 | 0.00 | |
| *4/*41 | 0.04 | 0.04 | 0.09 | |
| *4/*29 | 0.01 | 0.00 | 0.00 | |
| *6/*10 | 0.01 | 0.00 | 0.00 | |
| *6/*41 | 0.01 | 0.00 | 0.00 | |
| *3/*41 | 0.00 | 0.01 | 0.02 | |
| *4/*10 | 0.00 | 0.01 | 0.00 | |
| Poor metabolizer | *3/*3 | 0.01 | 0.00 | 0.00 |
| *3/*4 | 0.00 | 0.01 | 0.00 | |
| *4/*5 | 0.00 | 0.03 | 0.00 | |
| *4/*4 | 0.03 | 0.03 | 0.06 |