Table 4. Effect of moxidectin, Synriam, Synriam plus praziquantel and praziquantel against S. mansoni and malaria co-infections.
The study was carried out in the villages of Bigouin and Biakalé in western Côte d’Ivoire, between May and June 2015.
| Moxidectin (N = 31) | Synriam plus Praziquantel (N = 26) | Synriam (N = 30) | Praziquantel (N = 29) | |
|---|---|---|---|---|
| S. mansoni infection | ||||
| Children cured (%) (95% CI) | 4 (12.9) (0.03–0.3) | 7 (27.0) (0.1–0.5) | 2 (6.7) (0.01–0.2) | 8 (27.6) (0.1–0.5) |
| Children cured with high infection intensity (%) | 0/3 (0) | 2/6 (33.3) | 0/4 (0) | 1/5 (20.0) |
| Children cured with moderate infection intensity (%) | 2/13 (15.4) | 2/9 (22.2) | 0/13 (0) | 1/12 (8.3) |
| Children cured with low infection intensity (%) | 2/15 (13.3) | 3/11 (27.3) | 2/13 (15.4) | 6/12 (50.0) |
| EPG before treatment AM | 216.9 | 272.7 | 201.6 | 221.6 |
| EPG after treatment AM | 159.3 | 176.3 | 101 | 121.6 |
| EPG before treatment GM | 106.7 | 108.4 | 107 | 143.6 |
| EPG after treatment GM | 33.5 | 24.3 | 37.4 | 17.9 |
| Egg reduction rate (%) (95% CI) | 70.9 (0.4–0.9) | 77.6 (0.5–1.1) | 64.9 (0.4–0.8) | 87.5 (0.8–1) |
| CCA positive (tr+) before treatment N (%) | 28 (93.3) | 23 (88.5) | 25 (89.3) | 28 (96.5) |
| CCA positive (tr-) before treatment N (%) | 26 (86.6) | 20 (76.9) | 23 (82.0) | 28 (96.5) |
| CCA negative (tr+) after treatment N (%) | 5 (17.9) | 7 (30.4) | 5 (20.0) | 4 (14.3) |
| CCA negative (tr-) after treatment N (%) | 7 (27.0) | 8 (40.0) | 5 (21.7) | 7 (25.0) |
| Plasmodium falciparum infection | ||||
| No. RDT positive before treatment (%) | 22 (71.0) | 20 (77.0) | 24 (80.0) | 23 (79.0) |
| No. children negative based on RDT (%) | 1 (4.5) | 16 (80.0) | 23 (95.8) | 5 (21.7) |
CI, confidence interval; AM, arithmetic mean; GM, geometric mean, EPG, eggs per gram; tr+, trace considered as positive; tr-, trace considered as negative; RDT, rapid diagnostic test