Table 1. Patient characteristics within SCD discovery and replication cohorts.
| Characteristic | Discovery | Replication | ||||
|---|---|---|---|---|---|---|
| Elevated E/e’ (N = 18) | Normal E/e’ (N = 11) | P | Elevated E/e’ (N = 17) | Normal E/e’ (N = 14) | P | |
| Age (years ± SD) | 32.1 ± 8.5 | 31.5 ± 7.3 | 0.85 | 41.4 ± 11.5 | 27.5 ± 7.1 | 0.002 |
| Male (%) | 33 | 50 | 0.41 | 50 | 57 | 0.68 |
| Hgb SS genotype (%) | 94 | 90 | 0.67 | 87.5 | 90 | 0.64 |
| BSA (m2) | 1.75 ± 0.17 | 1.77 ± 0.19 | 0.86 | 1.85 ± 0.2 | 1.76 ± 0.1 | 0.72 |
| SBP (mmHg) | 118 ± 23.5 | 116 ± 6.2 | 0.80 | 135 ± 11.8 | 110 ± 10.9 | 0.006 |
| DBP (mmHg) | 65 ± 19.6 | 64 ±6.2 | 0.95 | 71.5 ± 13.1 | 62 ± 7.1 | 0.33 |
| LA Volume/BSA | 67.3 ± 16.9 | 67.4 ± 21.8 | 1 | 43.0 ± 12.7 | 51.3 ± 16.1 | 0.17 |
| LVEF (%) | 58.6 ± 6.1 | 60.4 ± 7.3 | 0.53 | 54.9 ± 7.7 | 58.6 ± 8.8 | 0.26 |
| TRV (m/s) | 2.41 ± 0.46 | 2.23 ± 0.35 | 0.35 | 2.24 ± 0.69 | 2.02 ± 0.38 | 0.88 |
| Hydroxyurea Therapy (%) | 33 | 50 | 0.73 | 36 | 40 | 0.76 |
| Hgb (g/dL) | 7.71 ± 1.20 | 8.78 ± 1.5 | 0.06 | 8.11 ± 1.7 | 8.65 ± 1.3 | 0.35 |
| Serum Creatinine (mg/dL) | 0.94 ± 0.61 | 0.64 ± 0.15 | 0.17 | 1.58 ± 1.9 | 0.81 ± 0.6 | 0.16 |
| >2 lifetime blood transfusions (%) | 72 | 70 | 0.91 | 86 | 93 | 0.55 |
SD: standard deviation; Hgb: hemoglobin; BSA: body surface area; SBP: systolic blood pressure; DBP; diastolic blood pressure; LA: left atrial; LVEF: left ventricular ejection fraction; TRV: tricuspid regurgitant velocity.