Table 2. Candidate genes associated with diastolic function in SCD discovery and replication cohorts.

Gene	Gene Name	Associated Phenotype	Correlation coefficient		Combined P	PCWP (replication cohort)
			Discovery	Validation		Correlation coefficient	P
FUCA2	Fucosidase, Alpha-L- 2, Plasma	Lateral E/e′	0.451	0.631	2.3 x 10−6	-0.299	0.271
ADAM9	ADAM Metallopeptidase Domain 9	Lateral E/e′	0.442	0.490	9.5 x 10−5	-0.153	0.484
IL18	Interleukin 18	Lateral E/e′	0.447	0.467	0.0001	0.190	0.385
PROSC	Proline Synthetase Co-Transcribed Homolog	Lateral E/e′	0.454	0.457	0.0001	-0.214	0.326
OR52N4	Olfactory Receptor, Family 52, Subfamily N, Member 4	Septal E/e′	-0.377	-0.433	0.0007	-0.434	0.038
SULT2B1	Sulfotransferase Family, Cytosolic, 2B, Member 1	Septal E/e′	0.418	0.385	0.0009	0.403	0.050
SLC16A2	Solute Carrier Family 16, Member 2 (Thyroid Hormone Transporter)	Septal E/e′	0.384	0.378	0.0016	-0.472	0.023