Table 1. Liver weight and function data, portal pressure, and hepatic tissue levels of Ang II and ET-1 in the different rat groups.
| G1 (n = 10) | G2 (n = 10) | G3 (n = 10) | G4 (n = 10) | G5 (n = 10) | |
|---|---|---|---|---|---|
| Liver weight (g) | 10.1 ± 1.8 | 9.8 ± 1.5 | 8.9 ± 1.1d | 9.4 ± 1.5 | 10.1 ± 1.6 |
| Liver-to-body weight ratio (%) | 2.4 ± 0.8 | 2.3 ± 0.9 | 2.6 ± 1.3 | 3.0 ± 1.9 | 3.0 ± 2.0 |
| TGF-β (ng/mg liver prot.) | 10.8 ± 2.1 | 11.2 ± 3.1 | 19.9 ± 2.7a | 21.3 ± 4.1a | 14.2 ± 3.2 |
| Bilirubin (mg/dl) | 0.2 ± 0.04 | 0.2 ± 0.03 | 2.8 ± 0.3a | 1.7 ± 0.3 | 1.0 ± 0.2 |
| Albumin (g/dl) | 3.5 ± 1.1 | 3.7 ± 1.2 | 2.2 ± 0.9a | 2.9 ± 0.9 | 3.0 ± 0.9 |
| AST (UI/L) | 51 ± 10 | 56 ± 16 | 143 ± 56b | 106 ± 50b | 174 ± 39b |
| ALT (UI/L | 24 ± 7 | 22 ± 2 | 69 ± 27b | 47 ± 22 | 66 ± 39b |
| Portal pressure (mmHg) | 6.2 ± 1.1 | 5.3 ± 0.8 | 24.3±2.05a | 19.0 ± 1 | 10.0±0.98 |
| Ang II (pg/mg of total liver protein) | 48 ± 10 | 52 ± 31 | 1400 ± 149b | 1209 ± 122 | 260 ± 99y |
| ET-1 (pg/mg of total liver protein) | 19.9 ± 3.7 | 16.6 ± 5.3 | 82.9 ± 16a | 63.5 ± 17 | 63.7 ± 12 |
Data are means ± SD. G1: control rats; G2: controls receiving 10 mg/kg b.w. SF2809E; G3: cirrhotic rats; G4: rats receiving both CCl4 and 10 mg/kg b.w. SF2809E; G5: rats receiving both CCl4 and 20 mg/kg b.w. SF2809E.
aP<0.01 versus G1 and G5.
bP<0.01 versus G1.
dP<0.03 versus every other group.
yP<0.03 versus G3. (Wilcoxon rank sum test).
TGF-β, transforming growth factor beta; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Ang-II, Angiotensin II; ET-1, endothelin-1.