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. 2016 Sep 16;11(9):e0162597. doi: 10.1371/journal.pone.0162597

Fig 1. Histology.

Fig 1

The figure depicts histological slides from mice exposed to ultraviolet radiation (UVR; a, b and c), 2) UVR and ingenol mebutate (UVR + IngMeb; d, e, and f) 3) UVR, IngMeb and clobetasol propionate (UVR + IngMeb = CP; g, h, and i) and 4) normal skin (j). Histological findings disclose that keratosis grade, epidermal hypertrophy, dysplasia, and actinic dermal damaged increased over time in mice receiving UVR alone (Rs = 0.82, p = 0.002), while repeated treatments with ingenol mebutate prevented progression of photodamage (Day 140; UVR 10.25 vs. UVR+IngMeb 6.00, p = 0.002). Concurrent treatments with CP potentiated the prophylactic effect of IngMeb with UV-damage scores similar to normal skin at day 140 (UVR+IngMeb+CP 3.00, Normal skin 3.00). * dermal actinic damage; ** dysplasia present in lower 2/3 of epidermis and an absent basal layer with the presence of a Zytoid body; *** parakeratosis.