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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Am J Psychiatry. 2016 Mar 4;173(6):588–599. doi: 10.1176/appi.ajp.2015.15070907

Table 3.

Adjusted Odds Ratios of 12-Month and Lifetime DSM-5 Cannabis Use Disorder and Psychiatric Disorders a

Adjusted Odds Ratio (95% Confidence Interval)
12-Month Cannabis Use Disorder Lifetime Cannabis Use Disorder
Any Cannabis Use Disorder Mild Moderate Severe Any Cannabis Use Disorder Mild Moderate Severe
Any other substance use disorder 9.3 (7.70–11.21) 7.4 (5.92–9.34) 12.2 (7.76–19.31) 13.1 (7.86–21.98) 14.5 (11.95–17.60) 10.5 (7.81–14.09) 19.4 (13.56–27.72) 21.9 (15.24–31.56)
Alcohol use disorder 6.0 (5.10–6.97) 5.1 (4.14–6.27) 7.7 (5.06–11.60) 6.8 (4.61–10.01) 7.8 (6.95–8.74) 6.1 (5.09–7.30) 9.6 (7.51–12.31) 10.1 (7.88–12.91)
Any other drug use disorder 9.0 (6.65–12.19) 6.6 (4.30–10.01) 11.5 (7.18–18.42) 13.4 (8.26–21.66) 10.0 (8.56–11.76) 7.9 (6.22–10.04) 9.2 (7.29–11.69) 14.6 (12.01–17.66)
Nicotine use disorder 6.2 (5.24–7.34) 4.8 (3.86–5.97) 7.3 (5.11–10.41) 10.5 (7.35–15.05) 6.6 (5.79–7.64) 5.1 (4.32–6.03) 7.9 (6.08–10.25) 8.9 (7.25–10.96)
Any mood disorder 3.8 (3.10–4.56) 2.8 (2.21–3.48) 3.5 (2.55–4.75) 8.1 (5.74–11.40) 3.3 (2.94–3.73) 2.3 (1.92–2.67) 3.4 (2.67–4.31) 5.6 (4.53–6.94)
Major depressive disorder 2.8 (2.33–3.41) 2.2 (1.77–2.84) 3.1 (2.29–4.23) 4.2 (2.76–6.40) 2.6 (2.26–2.95) 2.0 (1.65–2.47) 2.6 (2.05–3.33) 3.6 (2.97–4.34)
 Bipolar I 5.0 (3.65–6.75) 3.4 (2.16–5.47) 4.1 (2.29–7.22) 10.1 (6.32–16.08) 3.8 (3.10–4.59) 2.2 (1.52–3.27) 4.0 (2.82–5.80) 5.9 (4.53–7.75)
 Bipolar II 2.7 (1.10–6.62) 2.7 (0.80–9.46)b 3.4 (0.74–15.51) b 1.9 (0.42–8.18) b 2.8 (1.51–5.23) 2.3 (0.80–6.81) b 3.3 (1.35–8.24) 3.1 (1.34–7.26)
Any anxiety disorder 2.8 (2.24–3.39) 2.2 (1.64–2.93) 2.9 (2.02–4.03) 4.4 (2.96–6.56) 2.9 (2.54–3.31) 2.3 (1.87–2.73) 3.0 (2.29–4.05) 3.9 (3.16–4.86)
 Panic disorder 3.3 (2.50–4.48) 2.5 (1.58–3.84) 2.8 (1.60–5.04) 6.6 (3.74–11.58) 3.2 (2.66–3.76) 2.4 (1.85–3.20) 3.3 (2.29–4.72) 4.3 (3.18–5.72)
 Agoraphobia 2.6 (1.64–4.06) 2.4 (1.44–4.07) 3.5 (1.39–9.08) 2.0 (1.02–3.97) 2.9 (2.25–3.79) 2.1 (1.35–3.24) 3.9 (2.35–6.34) 3.5 (2.54–4.93)
 Social phobia 2.3 (1.61–3.27) 1.3 (0.74–2.21) b 3.5 (1.96–6.27) 3.9 (1.85–8.18) 2.7 (2.22–3.40) 2.0 (1.42–2.90) 2.6 (1.77–3.96) 4.0 (2.85–5.53)
 Specific phobia 1.7 (1.28–2.29) 1.4 (0.95–2.16) b 2.2 (1.28–3.65) 1.9 (1.21–3.14) 2.1 (1.73–2.46) 1.4 (1.04–1.91) 2.9 (2.00–4.07) 2.6 (2.01–3.24)
 Generalized anxiety disorder 3.7 (2.79–5.02) 3.0 (2.01–4.34) 3.6 (2.40–5.50) 6.3 (3.43–11.53) 3.2 (2.75–3.74) 2.5 (2.01–3.10) 3.4 (2.51–4.47) 4.3 (3.26–5.64)
Posttraumatic stress disorder 4.3 (3.26–5.64) 2.1 (1.34–3.30) 6.2 (3.98–9.59) 9.5 (6.18–14.75) 3.8 (3.15–4.67) 2.4 (1.81–3.21) 4.3 (3.16–5.85) 6.0 (4.55–7.88)
Any personality disorder 4.8 (3.96–5.75) 4.1 (3.30–4.99) 4.4 (3.01–6.31) 7.9 (4.98–12.59) 4.7 (4.18–5.28) 3.2 (2.76–3.74) 4.7 (3.65–5.95) 8.0 (6.34–10.19)
 Schizotypal 4.4 (3.60–5.46) 3.7 (2.85–4.90) 4.0 (2.82–5.63) 7.0 (4.60–10.62) 4.0 (3.46–4.72) 2.7 (2.16–3.35) 4.3 (3.26–5.60) 6.2 (4.84–7.98)
 Borderline 5.0 (4.13–6.10) 4.0 (3.13–5.15) 4.9 (3.30–7.12) 8.8 (5.83–13.41) 4.5 (3.96–5.19) 3.0 (2.49–3.53) 4.6 (3.52–6.05) 7.7 (6.17–9.67)
 Antisocial 3.8 (3.05–4.75) 3.5 (2.61–4.62) 3.9 (2.44–6.19) 4.6 (2.95–7.18) 4.7 (4.07–5.34) 3.5 (2.89–4.27) 4.4 (3.36–5.71) 6.7 (5.26–8.53)
a

Controlling for sex, age, race/ethnicity, marital status, education, family income, urban/rural, and region (Midwest, Northeast, South, West)

b

Except these odds ratios, all other odds ratios are significant (p < 0.05)