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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Breast Cancer Res Treat. 2016 Jun 1;157(3):461–474. doi: 10.1007/s10549-016-3839-3

Figure 4. Core needle biopsy of breast tumors trigger the recruitment of eosinophils to the biopsy wound.

Figure 4

(A) H&E staining of human breast tissue in the region adjacent to the biopsy (Adjacent) and a region far away (Distant) from to the biopsy wound. The images from 40x magnification (upper panels) and 400x magnification (lower panels) of the 40x-red labeled area are shown. Scale bars are shown. BW, biopsy wound. (B) Percentage of eosinophils (relative to all nucleated cells in the analyzed fields) in the regions adjacent and distant to the biopsy wound (n=43). p<0.0001, using a paired student’s t test analysis. (C) Percentage of eosinophils in the region adjacent to the biopsy wound, as a function of days between the core needle biopsy procedure and the surgical excision of the tumor tissue (n=43), p=0.019 using a regression analysis. (D) Percentage of eosinophils in the region adjacent to the biopsy wound in patients where surgical excision was performed within < 30 days (n= 29) or ≥ 30 days (n= 14) of the biopsy, p=0.013 using a Wilcoxon Rank Sums test. (E) Correlation of percentage of eosinophils and CD45+ cells in the < 30 days and ≥ 30 days groups. Within the ≥30d group ρ = 0.52 (p for simple effects= 0.0017), and within the <30d group ρ = −0.038 (p for simple effects= 0.91), as determined by regression analysis, including the time-by-CD45+ level interaction as a predictor (p for interaction=0.009).