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Dose Escalation Chart
| Dose Level | DOSE | ||||
|---|---|---|---|---|---|
| Vandetanib | Paclitaxel | Carboplatin | 5-FU | XRT | |
| Level 1 | 100 mg po qd | 50mg/m2/d qwk | AUC 5 q4wks | 225mg/m2/d PVI M-F | 1.8 Gy/d (total 45.0 Gy) |
| Level 2 | 200 mg po qd | 50mg/m2/d qwk | AUC 5 q4wks | 225mg/m2/d PVI M-F | 1.8 Gy/d (total 45.0 Gy) |
| Level 3 | 300 mg po qd | 50mg/m2/d qwk | AUC 5 q4wks | 225mg/m2/d PVI M-F | 1.8 Gy/d (total 45.0 Gy) |
