Table 1.

For the 12 glioma patients (6 IDH mutated and 6 no biopsy) enrolled in the study, the in-vivo estimated concentrations (mM) and CRLBs (% in parenthesis) of 2HG and other metabolites are tabulated together with the voxel size. G2 and G3 denote grade-II and grade-III gliomas respectively. IDH1 and IDH2 denote IDH1-mutated and IDH2-mutated gliomas respectively. O, oligodendroglioma; OA, oligoastrocytoma; A, astrocytoma; AA, anaplastic astrocytoma; AOA, anaplastic oligoastrocytoma.

	Voxel (mL)	2HG	GABA	Glu	Gln	tCho	tNAA
G2, OA, IDH1	4.5	6.2 (2)	0.4 (23)	1.2 (9)	3.1 (6)	1.8 (1)	1.2 (4)
G2, O, IDH2	6.4	4.6 (3)	0	1.5 (9)	2.1 (11)	1.5 (1)	2.4 (2)
G2, A, IDH1	15.6	1.2 (7)	0.3 (29)	2.1 (5)	0.5 (36)	2.4 (1)	3.1 (2)
G2, A, IDH1	8	1.0 (6)	0.2 (25)	1.0 (7)	1.3 (9)	1.3 (1)	1.7 (2)
G3, AA, IDH1	8	3.8 (5)	0	2.1 (5)	3.5 (4)	2.6 (1)	5.2 (2)
G3, AOA, IDH1	8	2.7 (7)	0.5 (46)	1.7 (15)	1.0 (43)	3.1 (1)	1.3 (3)
No biopsy	5.2	4.4 (3)	0	1.6 (9)	3.6 (6)	3.2 (0)	1.5 (3)
No biopsy	8	4.1 (6)	0	1.9 (6)	1.5 (9)	1.2 (1)	1.7 (2)
No biopsy	12.5	3.5 (5)	0	4.2 (5)	2.8 (10)	7.4 (0)	4.0 (2)
No biopsy	4.5	2.9 (6)	0	2.7 (8)	5.5 (7)	2.5 (1)	4.5 (2)
No biopsy	6	1.2 (5)	0	1.5 (5)	1.5 (8)	1.0 (1)	1.3 (3)
No biopsy	4.5	1.0 (5)	0	1.0 (6)	1.0 (10)	0.8 (1)	0.4 (4)