Table 1.

Multivariate Cox regression analysis showing the relationship between different covariates, including an interaction between WRN methylation and treatment arm, and progression free survival

Covariate	HR	95% CI	p-value*
treatment arm	0.47	0.32–0.70	0.0002
WRN methylation status	0.36	0.14–0.98	0.05
previous adjuvant therapy	1.65	1.09–2.50	0.02
serum LDH	1.52	1.07–2.15	0.02
WHO performance status	1.18	0.89–1.56	0.26
gender	0.74	0.52–1.04	0.09
age	0.99	0.98–1.01	0.51
location of metastases	1.10	0.85–1.43	0.45
interaction of treatment arm and WRN methylation status	2.11	1.13–3.92	0.02

Analysis based on 182 samples, of which 179 events (1 observation deleted due to missingness)

CI, confidence interval; HR, hazard ratio; WRN, Werner gene; LDH, Lactate dehydrogenase; WHO, World Health Organisation

^*Wald test