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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Exp Eye Res. 2016 Mar 16;156:22–33. doi: 10.1016/j.exer.2016.03.010

Figure 2. iSyTE predicts SIPA1l3 as a cataract gene.

Figure 2

iSyTE predicts SIPA1l3 as high-priority candidate gene in the lens among a 5Mb interval on human chromosome 19. Also see: (Lachke et al. 2012b). The color gradation in the inset offers an estimate of enriched expression of the genes in mouse lens tissue at embryonic day (E)10.5, E11.5 and E12.5. SIPA1l3 is among the top 1% of lens-enriched genes. This prediction was independently proven by two groups that recently reported SIPA1l3 mutations in human congenital cataract (Evers et al. 2015, Greenlees et al. 2015).