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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Exp Eye Res. 2016 Mar 16;156:22–33. doi: 10.1016/j.exer.2016.03.010

Figure 4.

Figure 4

Integrated network analysis to identify lens-specific Six3 interacting candidates. (A) Six3 lens perturbation data from published literature (evidence-based). (B) Expansion of Six3 evidence-based network using human protein-protein interaction (PPI) data for SIX3 to identify its immediate interacting partners (nodes). (C) Overlay of iSyTE expression data from E10.5 mouse lens tissue and P28 mouse lens isolated epithelium tissue on SIX3 PPI nodes, allowing the identification of high-priority lens relevant candidate nodes. (D) Overlay of iSyTE enriched expression data from E10.5 mouse lens tissue and P28 mouse lens isolated epithelium tissue on SIX3 PPI nodes, further refining the identification of high-priority candidates.