Table 1.

Representative drug-related adverse events (AEs) and associated dose ranges

Number of subjects	AE Type	AE Severity	Incidence	Range of AED doses
Carbamazepine
91–3011–3,5,6	Somnolence Decreased appetite	Mild/moderate	8–36% 2%	400–1200 mg/day
91–37815, 16, 18–21	Gastrointestinal	Mild/moderate	4–29%	400–2000 mg/day
91–37815–20	Rash	Mild/serious	8–32%	200–2000 mg/day
20–23017, 21, 22	Decreased white blood cells	Mild	Not reported	200–1400 (5–24 mg/kg/day)
Lamotrigine
8 – 33435, 39, 40	Rash	Moderate/serious	1%, 3%, 8%	100–500 mg (serious), 100 mg (moderate)
156 – 33437, 40	Stevens-Johnson syndrome	Serious	0. 1%, 1%	300–400 mg, 300 mg/day, and 250 mg bid
14136	Grand mal seizures	Serious	1%	300–400 mg/day
12638	Diplopia	Serious	1%	250 mg
33440	Dizziness	Serious	0. 6%	100–500 mg
33440	Blurry vision	Serious	0. 6%	100–500 mg
33440	Ataxia	Serious	0. 3%	100–500 mg
33440	Nausea	Serious	0. 3%	100–500 mg
Phenobarbital
11448	Elevated GGT	Mild	58%	NR
18–124e-ref 82, e- ref 83	Hypotension	NR	11–49%	10–30 mg/kg
1854	Intubation	Severe	33%	10–30 mg/kg
10–143 e-ref 71, e- ref 78	Somnolence	Mild	30%	8. 3–133. 3 mg/day
14350	Fatigue	Mild	21%	8. 3–133. 3 mg/day
Phenytoin
127–15159, 60	Rash	Moderate/serious	19% (mild), 8% (moderate), 2% (serious)	300 mg (serious)
114e-ref 61	Stevens-Johnson syndrome	Serious	1%	300 mg
14159	Suicide attempt	Serious	1%	300 mg
67e-ref 62	Myalgia	Moderate	2%	200–450 mg
Valproate
112e-ref 76	Somnolence	Mild	10–15%	1. 5–3. 0 mg/kg/min
112e-ref 76	Dizziness	Mild	8–10%	1. 5–3. 0 mg/kg/min
112e-ref 76	Nausea	Mild/moderate	8–10%	1. 5–3. 0 mg/kg/min
112e-ref 76	Paresthesia	Mild	8%	1. 5–3. 0 mg/kg/min

GGT: gamma-glutamyl transpeptidase