. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Clin Neuropharmacol. 2016 Sep-Oct;39(5):232–240. doi: 10.1097/WNF.0000000000000172

Table 3.

Narrow therapeutic index (NTI) classification. AED: antiepileptic drug.

AED	Articles meeting search criteria (Pubmed / Embase)	Full text articles reviewed	Articles from which data extracted	Therapeutic index	NTI classification supported by literature?
Carbamazepine	1022 / 344	364	34	3	Possibly
Lamotrigine	384 / 187	132	49	1. 3–20	Possibly
Phenobarbital	384 / 283	150	35	^**	No
Phenytoin	1007 / 284	111	34	2	Yes
Valproate	608 / 317	53	11	^**	No

^**

Therapeutic index could not be estimated due to poor correlation of toxicity symptoms with drug concentration.