(A) Mango, gallic acid, pomegranate, and ellagic acid lowered the expression of IGF-1R mRNA, whereas (B) pomegranate and ellagic acid decreased the expression of EGFR mRNA, 4 h after treatment. Values are the mean ± SEM (n=3 per group). Asterisk indicate significance compared to the control at p<0.05. (C) Western blot of IGF-1R and EGFR protein, 24 h after treatment with test agents. The number under each band represents protein expression (relative densitometry) normalized to β-actin.