Table 3.

Differentially expressed genes in colonic mucosa following mango and pomegranate treatment.

Symbol	Gene name	GenebankID	Relative expressiona	p-valueb	Relative expressiona	p-valueb
			Mango		Pomegranate
mTOR pathway
Ppp2r2b	Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform	NM_022209	2.993	0.026	2.792	0.037
Tp53	Tumor protein p53	NM_030989	2.585	0.045	2.367	0.049
Pld1	Phospholipase D1	NM_030992	0.342	0.049	0.350	0.044
Igf1	Insulin-like growth factor 1	NM_178866	0.573	0.038
Pik3cv	Phosphoinositide-3-kinase, catalytic, beta polypeptide	NM_053481	0.351	0.045
Insr	Insulin receptor	NM_017071	0.608	0.047
Vegfc	Vascular endothelial growth factor C	NM_053653			0.428	0.007
Rps6ka2	Ribosomal protein S6 kinase polypeptide 2	NM_057128			0.455	0.035
Rragd	Ras-related GTP binding D	NM_001106641			2.241	0.040
MAPK pathway
Ccne1	Cyclin E1	M_00110082	0.460	0.022	0.532	0.023
Pak1	P21 protein (Cdc42/Rac)-activated kinase 1	NM_017198	0.456	0.042	0.480	0.044
Tp53	Tumor protein p53	NM_030989	3.991	0.045	3.093	0.026
Map3k2	Mitogen activated protein kinase kinase kinase 2	NM_138503	0.570	0.047	0.639	0.032
Rac1	Ras-related C3 botulinum toxin substrate 1	NM_134366	0.489	0.017
Mapk10	Mitogen activated protein kinase 10	NM_012806	0.445	0.036
Mapk9	Mitogen-activated protein kinase 9	NM_017322	0.564	0.049
Map2k2	Mitogen activated protein kinase kinase 2	NM_133283			0.495	0.027
Cdc42	Cell division cycle 42 (GTP binding protein)	NM_171994			0.499	0.030
Mapk1	Mitogen activated protein kinase 1	NM_053842			0.432	0.036
Sfn	Stratifin	XM_232745			0.443	0.037

^aRelative expression was presented as a comparison of the experimental group to the control group.

^bNon-adjusted p values <0.05. After FDR adjustment for multiple testing, the p-values were non-significant.