Table 3.
Effects of Nitrite on Resting Hemodynamics
| Placebo | Nitrite | p | |
|---|---|---|---|
| Vital Signs | |||
| Heart rate (bpm) | −2±4 | −1±5 | 0.7 |
| Systolic BP (mmHg) | −0±7 | −3±16 | 0.6 |
| Mean BP (mmHg) | 1±3 | 0±9 | 0.8 |
|
| |||
| Central Pressures | |||
| RA (mmHg) | −1±1 | −2±2 | 0.05 |
| PA systolic (mmHg) | −5±6 | −12±6 | 0.01 |
| PA mean (mmHg) | −3±4 | −7±4 | 0.007 |
| PCWP (mmHg) | −1±2 | −4±3 | 0.002 |
|
| |||
| Vascular and Ventricular Function | |||
| PVR (mmHg/L/min) | −0.4±1.0 | −0.6±0.4 | 0.6 |
| PAC (ml/mmHg) | +0.6±0.9 | +1.5±1.1 | 0.046 |
| SVR (DSC) | +170±330 | +130±310 | 0.8 |
|
| |||
| Integrated Function and Metabolism | |||
| VO2 (ml/min) | +13±24 | +2±21 | 0.3 |
| CaO2 – CvO2 (ml/dl) | +0.7±1.2 | +0.5±1.0 | 0.6 |
| Cardiac index (l/min*m2) | −0.2±0.4 | −0.2±0.5 | 0.9 |
| SVI (ml/m2) | −1±6 | −2±8 | 0.7 |
Table shows baseline-corrected values (resting values after receiving study drug minus resting values prior to study drug administration).
BP, blood pressure; RA, right atrium; PA, pulmonary artery; PCWP, pulmonary capillary wedge pressure; PVR/SVR, pulmonary/systemic vascular resistance; PAC, pulmonary artery compliance; DSC, dyne/sec*cm5; LVSW, left ventricular stroke work; VO2, oxygen consumption; CaO2 – CvO2, arterial-venous O2 content difference; CO, cardiac output, SVI, stroke volume index