Table 4.
Effects of Nitrite on Exercise Hemodynamics
| Placebo (n=13) | Nitrite (n=13) | p | |
|---|---|---|---|
| Vital Signs | |||
| Heart rate (bpm) | −1±8 | −1±10 | 0.9 |
| Systolic BP (mmHg) | −4±8 | −5±9 | 0.7 |
| Mean BP (mmHg) | −1±3 | −4±5 | 0.07 |
|
| |||
| Central Pressures | |||
| RA (mmHg) | −2±3 | −5±3 | 0.02 |
| PA systolic (mmHg) | −7±9 | −11±6 | 0.2 |
| PA mean (mmHg) | −5±6 | −10±6 | 0.05 |
| PCWP (mmHg) | −3±5 | −9±6 | 0.02 |
|
| |||
| Vascular and Ventricular Function | |||
| PVR (mmHg/L/min) | −0.4±0.6 | −0.3±0.4 | 0.5 |
| PA compliance (ml/mmHg) | 0.4±0.7 | 0.5±0.7 | 0.6 |
| SVR (DSC) | −20±90 | −40±110 | 0.6 |
|
| |||
| Integrated Function and Metabolism | |||
| VO2 (ml/min) | −3±69 | 33±64 | 0.2 |
| CaO2 – CvO2 (ml/dl) | −0.3±0.9 | −0.0±0.7 | 0.4 |
| Cardiac index (l/min*m2) | 0.2±0.4 | 0.1±0.4 | 0.8 |
| SVI (ml/m2) | 2±5 | 1±7 | 0.6 |
Table shows exercise baseline-corrected values (exercise values after receiving study drug minus exercise values prior to study drug administration).
BP, blood pressure; RA, right atrium; PA, pulmonary artery; PCWP, pulmonary capillary wedge pressure; PVR/SVR, pulmonary/systemic vascular resistance; DSC, dyne/sec*cm5; LVSW, left ventricular stroke work; VO2, oxygen consumption; CaO2 – CvO2, arterial-venous O2 content difference; CO, cardiac output, SVI, stroke volume index