Table 1.

Cardiac valve anomalies were found in 1-4 month old FMOD and LUM deficient mice. The percentage of cardiac valve related anomalies are presented. Valve anchor anomalies i.e. MTLJ-myotendinous junction-like region are shown for the various genotypes. The bolded percentages of the Fmod−/−;Lum+/+, Fmod+/+;Lum−/−, Fmod−/−;Lum+/− and Fmod−/−;Lum−/−, indicate where malformations were at least double the percentage observed in WT (Fmod+/+;Lum+/+). For several malformations (valve anchors, AV and MV) the penetrance of the Fmod−/−;Lum+/− phenotype was higher than in hearts from single mutants (Fmod−/−;Lum+/+ and Fmod+/+;Lum−/−); in this case the percentile was bolded and underlined.

Age: 1 - 4 Months	Fmod +/+ Lum +/+ N=23	Fmod −/− Lum +/+ N=16	Fmod+/+ Lum −/− N=15	Fmod −/− Lum +/− N=13	Fmod −/− Lum −/− N=3
Valve Anchor Anomalies (MTJL)	0%	44%	27%	77%	100%
Pulmonary Valve Anomalies	17%	53%	7%	40%	66%
Bicuspid	0%	34%	0%	31%	66%
Aortic Valve Anomalies	26%	20%	20%	46%	100%
Bicuspid	22%	0%	13%	31%	100%
Mitral Valve Anomalies	0%	43%	13%	77%	66%
Tricuspid Valve Anomalies	0%	13%	7%	23%	66%