Fig. 3.

Chromatin state and histone modifications at MIR ECRs in the brain and embryonic tissues. Data from the Roadmap Epigenomics Consortium shows that MIR 1, 2 and 6 (3a, b and f) are active regulators of transcription in many areas of the human brain, whereas MIR 3, 4, and 5 (3c, d and e) are active in embryonic and induced pluripotent stem cells, and may function to regulate transcription at this locus during development. Chromatin states: Enh = enhancer, EnhA1/2 = active enhancer 1 or 2, EnhAc = enhancer acetylation only, EnhAF = active enhancer flank, EnhW1/2 = weak enhancer 1 or 2, PromP = poised promoter, PromU = promoter upstream transcriptional start site, TssA = active transcription start site, TssAFlank = flanking active transcriptional start site. Histone modifications: Enh = enhancer, Pro = promoter. Black = no available data