Fig. 3.

Effects of monocrotaline-induced pulmonary hypertension in rat on expression of regulators of protein synthesis and degradation in the right ventricle. Expression levels of insulin-like growth factor (IGF)-1Ea and mechano growth factor (MGF) mRNA are presented relative to 18S (a), as concentration per milligram heart tissue (b) or per nucleus (c). Expression levels of muscle RING-finger protein-1 (MuRF1), muscle atrophy F-box (Mafbx), and BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) were analyzed as markers of degradation and shown relative to 18S (d), as concentration (e) and per nucleus (f). Note that the right axis in d applies only to BNIP3 expression levels. ***p < 0.001, **p < 0.01, *p < 0.05. White bars: control, black bars: PH