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. 2016 May 18;41(11):2647–2657. doi: 10.1038/npp.2016.60

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Copyright © 2016 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Treatment and genotype effects on ad libitum calorie consumption. (Top left) Treatment effects of GSK1521498 and NTX (least square mean difference compared with placebo; y axis) in the ad libitum buffet paradigm on average over genotype. (Top right) Treatment effects of GSK1521498 and NTX (least square mean difference compared with placebo; y axis) in the ad libitum snacking paradigm on average over genotype. (Bottom left) Treatment effects of GSK1521498 and NTX (least square mean difference compared with placebo; y axis) for the buffet paradigm, plotted separately by genotype (AA or G+). (Bottom right) Treatment effects of GSK1521498 and NTX (least square mean difference compared with placebo; y axis) for the snacking paradigm, plotted separately by genotype (AA or G+). Statistically significant effects are highlighted: *P<0.05, **P<0.01, ***P<0.001 for treatment versus placebo.