Intracerebroventricular (ICV) CRF impairs working memory. Shown are the effects of ICV-administered vehicle (n=9) and varying doses of CRF (0.1 μg CRF, n=7; 0.2 μg CRF, n=8; 1 μg CRF, n=8) on working memory performance as measured by percentage change in correct trials (accuracy) from baseline. Results represent mean±SEM percentage change in correct trials (accuracy) from baseline. *P<0.05, **P<0.01, ***P<0.001 vs vehicle.