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. 2016 Jul 6;41(11):2772–2781. doi: 10.1038/npp.2016.91

Figure 1.

Figure 1

(a) Results from microdialysis experiment 1, time course of heroin, 10, 18, and 32 micrograms/kg, i.v., injected 30 min apart, on DA levels in dialysates from the NAS, 10 min after pretreatments with (+)-naltrexone ((+) NTRX), 17 or 32 mg/kg or saline, s.c. Pretreatments were repeated at 60 min in order to avoid any potential fading of their pharmacological effects. Data are expressed as percentage of basal values±SEM. (b) Results for microdialysis experiment 2, time course of administration of cocaine, 0.10, 0.32, and 1.0 mg/kg i.v., injected 30 min apart, on DA levels in dialysates from the NAS, 10 min after pretreatments with NTRX, 17 mg/kg s.c., or saline. Pretreatments were repeated at 60 min in order to avoid any potential fading of (+)-naltrexone effects. Data are expressed as percentage of basal values±SEM.