Figure 4.
Cdk3 may initiate meiosis together with Cyc2. (A) Distribution of abundances changes of phosphorylated peptides between cdk3Δ and WT cells (log2[Lcdk3Δ/LWT], details see Fig. S2). (B) Relative abundance (log2[LSample/HWT], details see Fig. S2) of phosphorylated Cyc2 in WT and cdk3Δ cells. (C) The phosphorylation site in Cyc2. (D) CDK3 and CYC2 are co-expressed in WT cells. (E) Expression profiles of core meiotic genes in cdk3Δ, cyc2Δ and spo11Δ cells. Values for cyc2Δ expression were retrieved from NCBI (GSE79286) and those for spo11Δ expression from TetraFGD. (F) Relationship among Cdk3, Cyc2, and proteins that function in early meiosis. Green arrow, promote genes function at their expression level; orange arrow, promote an event by a phosphorylation pathway; gray arrow, perform the function in the meiosis events.