Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesth Analg. 2016 Nov;123(5):1210–1219. doi: 10.1213/ANE.0000000000001234

Figure 5. Methylphenidate does not induce significant electroencephalogram changes during continuous inhalation of 2.0% isoflurane.

Figure 5

(A) A representative electroencephalogram recorded from a rat inhaling 2.0% isoflurane, with time=0 indicating the start of methylphenidate (5 mg/kg IV) injection. The electroencephalogram remained in a burst suppression pattern after methylphenidate was administered. (B) A spectrogram computed from the same animal shows that methylphenidate did not induce significant changes in spectral power. (C) Power spectral densities computed from burst periods 2-minutes pre- and post-methylphenidate, and their 95% confidence intervals (with Bonferroni correction), were constructed around the mean spectra across all rats (n = 6). Methylphenidate did not induce significant changes in the power spectrum.