Table 1.
Multivariate Cox Proportional Hazard Analysis of Incident Anti-psychotic Drug Use Among Socio-Demographic Factors, Level of Cognitive Impairment as Measured by CDR, and Severity of Neuropsychiatric Symptoms.
| Model I | Model II | Model III | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Primary Predictor of Interest | ||||||
| Race/Ethnicity | ||||||
| Hispanic: White | 1.72 | (1.29, 2.29) | 1.58 | (1.18, 2.09) | 1.58 | (1.19, 2.11) |
| African American: White | 1.13 | (0.86, 1.51) | 1.17 | (0.88, 1.55) | 1.20 | (0.90, 1.59) |
| Key Predictors | ||||||
| Sociodemographic | ||||||
| Age from 70 | ||||||
| Effect of 1 year increase | 0.97 | (0.97, 0.98) | 0.98 | (0.97, 0.99) | 0.98 | (0.97, 0.98) |
| Sex | ||||||
| Female compared to male | 0.73 | (0.62, 0.86) | 0.80 | (0.68, 0.94) | 0.73 | (0.62, 0.86) |
| Education | ||||||
| <HS compared to HS | 0.87 | (0.63, 1.20) | 0.89 | (0.65, 1.22) | 0.89 | (0.65, 1.23) |
| College compared to HS | 0.96 | (0.78, 1.19) | 0.95 | (0.77, 1.17) | 0.93 | (0.75, 1.14) |
| Graduate education compared to HS | 1.06 | (0.87, 1.30) | 1.07 | (0.87, 1.3) | 1.04 | (0.85, 1.28) |
| NeuroPsych SymptomsSeverity | ||||||
| NPS Sum of Boxes | 1.08 | (1.06, 1.09) | 1.07 | (1.05, 1.08) | ||
| Clinical Dementia Rating | ||||||
| CDR Sum of Boxes | 1.06 | (1.04, 1.08) | ||||
*
Results in bold are significant at p<0.05, CI= confidence interval, HS= high school, HR= hazard ratio, NPS = NeuroPsych Symptom Severity, CDR = Clinical Dementia Rating