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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Dev Biol. 2016 Mar 17;419(1):156–164. doi: 10.1016/j.ydbio.2016.03.020

Figure 1.

Figure 1

The auxin signaling pathway. (a) In low auxin conditions, the activity of AUXIN RESPONSE FACTOR (ARF) transcription factors is inhibited by interactions with Auxin/INDOLE-3-ACETIC ACID (Aux/IAAs) repressor proteins and the co-repressor TOPLESS (TPL). (b) Auxin acts a molecular glue between TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX PROTEINS (TIR1/AFBs) and Aux/IAAs, leading to ubiquitination and proteasome-mediated degradation of the Aux/IAAs. This relieves repression on the ARFs, allowing auxin-induced transcription to proceed. This simplified schematic incorporates the essential players and logic of auxin response, but does not include the higher order complexes resulting from homo- and heterotypic interactions among many of these components.