Skip to main content
. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Mar 17;106(Pt A):45–62. doi: 10.1016/j.addr.2016.03.003

Figure 4.

Figure 4

Mechanism of gene delivery by T4 capsid-based nanoparticles. A) Initiation of DNA packaging by aggregation of gp17; B) DNA encapsulation into the head by ATP utilization; C) Adding the Soc proteins; D) Fusing the Hoc- targeting peptide; E) Nonspecific binding of the nanoparticle to the cell surface; F) Receptor mediated binding to the cell surface; G) As a result of cell binding internalization takes place; (H and I) Either the transferred gene produces the displayed peptide such as beta-galactosidase; (K, L,M) Or DNA is transformed in the nucleus and encodes the desired protein such as luciferase (Reprinted from ref.[113] with permission from PNAS).