Table 1. Comparison of Study Participants With and Without Schizophrenia.
Healthy Comparison (HC) | Schizophrenia | t | df | p | Cohen's d | |||||
---|---|---|---|---|---|---|---|---|---|---|
N | Mean | Std Dev | N | Mean | Std Dev | |||||
Sociodemographic Factors | ||||||||||
Age (years) | 120 | 48.6 | 11.6 | 134 | 48.1 | 10.1 | 0.34 | 237.4 | 0.731 | 0.044 |
Gender (% women) | 54% | 45% | 2.23* | 1 | 0.167 | 1.49** | ||||
Education (years) | 120 | 14.5 | 2.2 | 134 | 12.4 | 2.0 | 8.00 | 243.4 | <0.001 | |
Current packs of cigarettes per day | 120 | 0.02 | 0.08 | 134 | 0.38 | 0.48 | -8.5 | 142.4 | <0.001 | -1.04 |
Number of years smoked | 120 | 5.4 | 10.6 | 133 | 16.3 | 14.7 | -6.83 | 239.2 | <0.001 | -0.84 |
Substance Abuse (Yes) | 19 | 15% | 55 | 41% | 19.85* | 1 | <0.001 | 4.45** | ||
Clinical Factors | ||||||||||
Duration of illness (years) | 133 | 25.1 | 11.2 | |||||||
Antipsychotic dose*** | 134 | 1.8 | 1.5 | |||||||
PHQ-9 Score | 116 | 2.0 | 2.9 | 130 | 7.6 | 6.6 | -8.72 | 182.0 | <0.001 | -1.29 |
Positive symptoms† | 119 | 0.3 | 0.7 | 134 | 6.5 | 4.3 | -16.63 | 141.4 | <0.001 | -2.80 |
Negative symptoms‡ | 118 | 1.4 | 2.3 | 134 | 7.4 | 4.4 | -13.93 | 203.6 | <0.001 | -1.95 |
SF-36 Mental Composite score | 117 | 54.6 | 5.8 | 132 | 43.4 | 11.3 | 9.97 | 201.7 | <0.001 | 1.40 |
Executive function | 120 | 0.4 | 0.6 | 134 | -0.5 | 0.7 | 11.63 | 249.9 | <0.001 | 1.47 |
Physical Factors | ||||||||||
SF-36 Physical Composite Score | 117 | 51.5 | 8.8 | 132 | 43.2 | 10.1 | 6.99 | 247.0 | <0.001 | 0.89 |
CIRS Total score | 101 | 3.2 | 3.2 | 116 | 6.8 | 4.9 | -6.45 | 200.3 | <0.001 | -0.91 |
BMI (kg/m2) | 117 | 27.7 | 7.0 | 132 | 32.2 | 7.4 | -4.90 | 245.7 | <0.001 | -0.63 |
hs-CRP (mg/L) | 116 | 2.18 | 3.5 | 131 | 5.08 | 8.8 | -3.47 | 174.7 | 0.001 | -0.53 |
Plasma F2-isoprostanes (ng/mL) | 120 | 0.032 | 0.015 | 134 | 0.040 | 0.021 | -3.31 | 243.4 | 0.001 | -0.43 |
X2 value
r value
Antipsychotic medication daily dosages were converted to WHO average daily doses based on published standards (WHO, 2009, 2010)
Scale for the Assessment of Positive Symptoms (SAPS) total score
Scale for the Assessment of Negative Symptoms (SANS) total score
PHQ-9 = patient health questionnaire
SF = Short Form Health Survey
CIRS = Cumulative Illness Rating
BMI = body mass index
hs-CRP = high sensitivity C-reactive protein