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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: J Immunol. 2016 Aug 24;197(7):2816–2827. doi: 10.4049/jimmunol.1600598

Figure 3. Mincle or Syk blockade are protective in Con-A hepatitis but Mincle ligation exacerbates disease.

Figure 3

(a, b) WT mice were treated with Con-A alone or in combination with a neutralizing α-Mincle mAb (n=5/group). (a) Livers were harvested at 12h and the fraction of necrotic liver area was calculated based on H&E staining. (b) Serum levels of pro-inflammatory cytokines were tested. (c, d) WT mice were treated with Con-A alone or in combination with the Syk inhibitor Piceatannol (n=5/group). (c) Livers were harvested at 12h and the fraction of necrotic liver area was calculated based on H&E staining. (d) Serum levels of pro-inflammatory cytokines were tested. (e, f) WT mice were treated with PBS, TDB alone, Con-A alone, or Con-A + TDB (n=5/group). (e) Livers were harvested at 12h and the fraction of necrotic liver area was calculated based on H&E staining. (f) Serum levels of pro-inflammatory cytokines were tested (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).