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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Psychiatr Res. 2016 Jul 18;82:58–67. doi: 10.1016/j.jpsychires.2016.07.012

Table 2.

Validated mRNA targets of miR-34a with linkage to neuropsychiatric illness. Gene names in bold represent novel mRNA targets.

Gene Gene Description
GRM7 Metabotropic Glutamate Receptor 7 Synaptic transmission GWAS (BP)(Fleischhacker et al., 1992, Zhou et al., 2009)
ANK3 Ankyrin G Actin/spectrin adaptor protein GWAS (BP)(Bavamian et al., 2015)
CACNB3 Voltage-Dependent L-Type Clacium Channel Subunit Beta-3 Synaptic transmission GWAS (BP)(Bavamian et al., 2015)
VEGFA Vascular Endothelial Growth Factor A Growth factor signaling Dysregulation of mRNA and protein levels, linkage analysis (MDD)(Berent et al., 2014, Tsai et al., 2009)
NCOA1 Nuclear Receptor Co-Activator 1 Modulation of gene transcription via glucocorticoid receptor Dysregulation of mRNA levels (BP), modulation of stress responses and HPA axis activity. (Lachize et al., 2009, Winnay et al., 2006)
NCOR2 Nuclear Receptor Co-Repressor 2 Modulation of gene transcription via glucocorticoid receptor Dysregulation of mRNA levels (MDD)
PDE4B cAMP-specific 3',5'-cyclic Phosphodiesterase 4B Regulates synaptic transmission via controlling cAMP levels Dysregulation of protein levels (MDD), SNP (SZ and BP)(Fatemi et al., 2008, Pickard et al., 2007, Yuan et al., 2011)
SIRT1 Sirtuin 1 Histone deacetylase Dysregulation of mRNA levels (BP, MDD)(Abe, 2011)