Table 1.
Biological pathways in the two comparisons (Disease vs. Health; RvE1 (0.5μg/μl) vs. Disease)
| Disease vs. Health | RvE1(0.5μg/ml) vs. Disease | ||
|---|---|---|---|
| Pathways | False Discovery Rate (FDR) | Pathways | False Discovery Rate (FDR) |
| Phagosome | 2.35E-09 | *Chemokine signaling pathway | 6.98E-05 |
| Lysosome | 4.01E-09 | Salmonella infection | 2.18E-03 |
| Protein digestion and absorption | 1.18E-07 | TNF signaling pathway | 1.03E-02 |
| Hematopoietic cell lineage | 3.10E-06 | *Chagas disease (American trypanosomiasis) | 1.03E-02 |
| Tuberculosis | 3.88E-05 | NOD-like receptor signaling pathway | 1.03E-02 |
| *Rheumatoid arthritis | 8.20E-05 | Legionellosis | 1.03E-02 |
| *Chemokine signaling pathway | 8.41E-05 | PPAR signaling pathway | 2.07E-02 |
| Renin-angiotensin system | 8.41E-05 | *Rheumatoid arthritis | 2.07E-02 |
| Leishmaniasis Antigen processing and presentation | 8.41E-05 | *Bile secretion | 3.38E-02 |
| *Osteoclast differentiation | 9.69E-05 | *Osteoclast differentiation | 3.75E-02 |
| ECM-receptor interaction | 1.53E-04 | ||
| Systemic lupus erythematosus | 1.54E-04 | ||
| Staphylococcus aureus infection | 2.13E-04 | ||
| Asthma | 2.13E-04 | ||
| Cytokine-cytokine receptor interaction | 3.93E-04 | ||
| Inflammatory bowel disease (IBD) | 7.15E-04 | ||
| Intestinal immune network for IgA production | 1.04E-03 | ||
| Amoebiasis | 1.17E-03 | ||
| Graft-versus-host disease | 1.46E-03 | ||
| Focal adhesion | 1.97E-03 | ||
| Type I diabetes mellitus | 2.39E-03 | ||
| *Pancreatic secretion | 5.28E-03 | ||
| Leukocyte transendothelial migration | 5.82E-03 | ||
| Autoimmune thyroid disease | 6.05E-03 | ||
| Allograft rejection | 6.05E-03 | ||
| Natural killer cell mediated cytotoxicity | 7.68E-03 | ||
| Herpes simplex infection | 8.45E-03 | ||
| Malaria | 9.14E-03 | ||
| Primary immunodeficiency | 1.17E-02 | ||
| Platelet activation | 1.27E-02 | ||
| PI3K-Akt signaling pathway | 1.45E-02 | ||
| *Chagas disease (American trypanosomiasis) | 2.43E-02 | ||
| *Bile secretion | 2.43E-02 | ||
| Complement and coagulation cascades | 4.41E-02 | ||
| Platelet activation | 1.27E-02 | ||
The biological pathways found by using impact analysis are listed by the order of false discovery rate (<0.05).
*
The common pathways are in boldface.