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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Acta Neuropathol. 2016 Jul 29;132(4):545–561. doi: 10.1007/s00401-016-1600-y

Fig. 10.

Fig. 10

Calcineurin protects against the accumulation of neurotoxic pTDP. (a) Under normal cellular conditions, low levels of pTDP are generated and rapidly cleared through the action of the phosphatase calcineurin. (b) During an acute cellular stress or following dysregulation or inhibition of calcineurin, the balance between non-phosphorylated and phosphorylated TDP-43 is shifted towards production of pTDP, leading to neuronal dysfunction and eventual cell death.